Senior Software Engineer

About Tempus AI Tempus is making precision medicine a reality by applying AI in healthcare, deriving insights from our expansive library of clinical data and molecular data. We enable physicians to make real-time, data-driven decisions to deliver personalized care and targeted therapies for patients through our analytical machine learning platform that uses the power of artificial intelligence in healthcare. We also work with partners to facilitate discovery, development, and delivery of optimized therapeutic options for patients through distinctive solution sets. Our mission is for each patient to benefit from the treatment of others who came before by providing the healthcare industry tools that learn as we gather more data. It’s About Time. For more information, visit tempus.com.

Tempus AI

Tempus AI, Inc. (NASDAQ: TEM) is a technology company leading the adoption of AI to advance precision medicine.

T

tempus.com

1,001-5,000 employees

Biotechnology Research

Chicago, IL

2015

Public Company

130k LinkedIn followers

Raised $2.8B

• At Tempus, we're leveraging cutting-edge technology to transform healthcare through AI-powered insights. Our proprietary platform connects real-world evidence to deliver actionable intelligence to physicians, ensuring the right treatments reach the right patients at precisely the right time.
• We operate in small, autonomous teams where developers, designers, scientists, and product managers collaborate closely. You'll have direct ownership in building solutions that make a meaningful impact in cancer research and treatment. Our agile approach and modern architecture enable us to innovate rapidly while maintaining the highest standards of quality and scalability.

Required

• 5+ years of advanced TypeScript/JavaScript/python development with a deep understanding of language features and optimization techniques.
• Extensive experience architecting and leading development with Node.js and NestJS frameworks.
• Experience with React development with a demonstrated ability to design and implement complex component systems.
• Proven experience building, scaling, and maintaining bioinformatics orchestration pipelines for high-throughput genomic data analysis using workflow frameworks such as Nextflow.
• Hands-on experience managing, monitoring, and optimizing workflow executions via Seqera Platform (Nextflow Tower) across cloud environments.
• Hands-on experience leveraging GenAI coding tools and autonomous agents (e.g., Copilot, Cursor, LLM APIs) to accelerate development, refactor codebases, and auto-generate comprehensive unit/integration tests.
• Experience or strong working knowledge of integrating APIs and GenAI technologies into production applications.
• Advanced PostgreSQL skills including query optimization, indexing strategies, and performance tuning.
• Proven expertise implementing sophisticated Redis caching solutions for high-throughput systems.
• Demonstrated success designing and implementing distributed microservice architectures that seamlessly interface with data-intensive bioinformatic workflows.
• Significant experience orchestrating infrastructure and applications on GCP, including CI/CD pipelines and cloud-based compute backends for pipeline execution.
• Mastery of enterprise-level design patterns and their practical application in large-scale, mission-critical systems.
• 7+ years of software development experience with a track record of technical leadership.
• Ability to make high-impact architectural decisions that balance business needs, data infrastructure constraints, and scientific computing requirements.
• Track record of bridging the gap between software engineering and computational biology/bioinformatics teams to streamline workflow execution and data delivery.
• Enthusiasm for championing AI-assisted development practices, driving adoption of agentic workflows, and mentoring teams through the evolving landscape of AI tools.
• History of successfully delivering complex projects in fast-paced environments.
• Strong communication skills with experience presenting technical solutions to diverse stakeholders.
• Proven ability to drive cross-team technical initiatives and resolve complex engineering challenges.

Preferred

• Advanced expertise in Nextflow (DSL2) custom module/subworkflow development and integration with cloud-native storage/compute engines (e.g., GCP Batch, Life Sciences API, or AWS Batch).
• Experience with search technologies such as Elasticsearch or OpenSearch.
• Experience with containerization orchestration (Docker, Kubernetes).
• Background in biotech, genomics, or precision medicine.
• The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

• Incentive compensation
• Restricted stock units
• Medical benefits